| Month | Game | + | Away | Pitcher | At | Home | Pitcher |
| August | 1 | YDR | Justin Verlander | At | CHI | Tim Hudson | |
| August | 2 | YDR | Erik Bedard* | At | CHI | Ryan Vogelsong | |
| August | 3 | YDR | Trevor Cahill | At | CHI | Freddy Garcia | |
| August | 4 | CAL | Aaron Harang | At | YDR | Kyle Lohse | |
| August | 5 | CAL | Daniel Hudson | At | YDR | Justin Verlander | |
| August | 6 | CAL | Dustin Moseley | At | YDR | Bruce Chen* | |
| August | OFF | ||||||
| August | 7 | + | YDR | Trevor Cahill | At | NIM | Justin Masterson |
| August | 8 | + | YDR | Erik Bedard* | At | NIM | Zack Greinke |
| August | 9 | + | YDR | Justin Verlander | At | NIM | Clayton Kershaw* |
| August | 10 | + | YDR | Kyle Lohse | At | NIM | Ubaldo Jimenez |
| August | 11 | + | YDR | Bruce Chen* | At | NIM | Justin Masterson |
| August | 12 | + | TAM | Jeff Niemann | At | YDR | Trevor Cahill |
| August | 13 | + | TAM | Tim Stauffer | At | YDR | Justin Verlander |
| August | 14 | + | TAM | Ted Lilly* | At | YDR | Erik Bedard* |
| August | 15 | + | TAM | Ryan Dempster | At | YDR | Kyle Lohse |
| August | OFF | ||||||
| August | 16 | YDR | Bruce Chen* | At | DYE | Jeff Karstens | |
| August | 17 | YDR | Trevor Cahill | At | DYE | Gavin Floyd | |
| August | 18 | YDR | Justin Verlander | At | DYE | Chris Volstad | |
| August | 19 | SSB | Doug Fister | At | YDR | Erik Bedard* | |
| August | 20 | SSB | Henderson Alvarez | At | YDR | Kyle Lohse | |
| August | 21 | SSB | Clayton Richard* | At | YDR | Bruce Chen* | |
| August | 22 | BUR | Randy Wolf* | At | YDR | Justin Verlander | |
| August | 23 | BUR | Carl Pavano | At | YDR | Trevor Cahill | |
| August | 24 | BUR | Brad Bergesen | At | YDR | Erik Bedard* | |
| + Indicates In Division Game | |||||||