| Month | Game | + | Away | Pitcher | At | Home | Pitcher |
| September | 1 | DET | Johnny Cueto | At | NIM | David Phelps | |
| September | 2 | DET | Homer Bailey | At | NIM | Justin Masterson | |
| September | 3 | DET | Jered Weaver | At | NIM | Carlos Villanueva | |
| September | 4 | HUC | James Shields | At | DET | Mike Fiers | |
| September | 5 | HUC | R.A. Dickey | At | DET | Johnny Cueto | |
| September | 6 | HUC | Roy Halladay | At | DET | Jaime Garcia* | |
| September | OFF | ||||||
| September | 7 | + | EGH | Jake Westbrook | At | DET | Jered Weaver |
| September | 8 | + | EGH | Joe Saunders* | At | DET | Johnny Cueto |
| September | 9 | + | EGH | Matt Harrison* | At | DET | Mike Fiers |
| September | 10 | + | EGH | Tommy Milone* | At | DET | Wandy Rodriguez* |
| September | 11 | + | EGH | Nathan Eovaldi | At | DET | Homer Bailey |
| September | 12 | + | DET | Johnny Cueto | At | CHI | Tim Hudson |
| September | 13 | + | DET | Jaime Garcia* | At | CHI | Matt Cain |
| September | 14 | + | DET | Mike Fiers | At | CHI | Kevin Millwood |
| September | 15 | + | DET | Wandy Rodriguez* | At | CHI | Jeff Samardzija |
| September | OFF | ||||||
| September | 16 | + | DET | Jered Weaver | At | DYE | Felix Hernandez |
| September | 17 | + | DET | Johnny Cueto | At | DYE | Kris Medlen |
| September | 18 | + | DET | Mike Fiers | At | DYE | Erasmo Ramirez |
| September | 19 | + | DET | Wandy Rodriguez* | At | DYE | Ted Lilly* |
| September | 20 | + | DET | Homer Bailey | At | DYE | Felix Hernandez |
| September | 21 | + | CHI | Tim Hudson | At | DET | Jaime Garcia* |
| September | 22 | + | CHI | Matt Cain | At | DET | Johnny Cueto |
| September | 23 | + | CHI | Kevin Millwood | At | DET | Wandy Rodriguez* |
| September | 24 | + | CHI | Jeff Samardzija | At | DET | Mike Fiers |
| + Indicates In Division Game | |||||||