| Month | Game | + | Away | Pitcher | At | Home | Pitcher |
| September | 1 | DUB | Andrew Cashner | At | DET | Johnny Cueto | |
| September | 2 | DUB | Jeanmar Gomez | At | DET | Clay Buchholz | |
| September | 3 | DUB | Ubaldo Jimenez | At | DET | Rick Porcello | |
| September | 4 | DET | Joe Saunders* | At | SRD | Alexander Cobb | |
| September | 5 | DET | Homer Bailey | At | SRD | Jeremy Hellickson | |
| September | 6 | DET | Johnny Cueto | At | SRD | John Danks* | |
| September | OFF | ||||||
| September | 7 | + | DET | Clay Buchholz | At | CHI | Jhoulys Chacin |
| September | 8 | + | DET | Joe Saunders* | At | CHI | Scott Feldman |
| September | 9 | + | DET | Jose D. Fernandez | At | CHI | Jeff Samardzija |
| September | 10 | + | DET | Johnny Cueto | At | CHI | Tim Hudson |
| September | 11 | + | DET | Homer Bailey | At | CHI | Jhoulys Chacin |
| September | 12 | + | DYE | Shelby Miller | At | DET | Bruce Chen* |
| September | 13 | + | DYE | Bartolo Colon | At | DET | Joe Saunders* |
| September | 14 | + | DYE | Kris Medlen | At | DET | Jose D. Fernandez |
| September | 15 | + | DYE | Tyler Chatwood | At | DET | Clay Buchholz |
| September | OFF | ||||||
| September | 16 | + | GOB | Adam Wainwright | At | DET | Rick Porcello |
| September | 17 | + | GOB | Aaron Harang | At | DET | Johnny Cueto |
| September | 18 | + | GOB | Dan Haren | At | DET | Jered Weaver |
| September | 19 | + | GOB | Edwin Jackson | At | DET | Clay Buchholz |
| September | 20 | + | GOB | Adam Wainwright | At | DET | Homer Bailey |
| September | 21 | + | DET | Bruce Chen* | At | DYE | Bartolo Colon |
| September | 22 | + | DET | Johnny Cueto | At | DYE | Shelby Miller |
| September | 23 | + | DET | Joe Saunders* | At | DYE | Tyler Chatwood |
| September | 24 | + | DET | Jered Weaver | At | DYE | Kris Medlen |
| + Indicates In Division Game | |||||||