| Month | Game | + | Away | Pitcher | At | Home | Pitcher |
| September | 1 | SYI | Travis Wood* | At | YDR | Garrett Richards | |
| September | 2 | SYI | Hyun-Jin Ryu* | At | YDR | Dillon Gee | |
| September | 3 | SYI | Martin Perez* | At | YDR | C.J. Wilson* | |
| September | 4 | CHI | Tyler Thornburg | At | SYI | Doug Fister | |
| September | 5 | CHI | Jeff Samardzija | At | SYI | Yovani Gallardo | |
| September | 6 | CHI | Matt Cain | At | SYI | Travis Wood* | |
| September | OFF | ||||||
| September | 7 | GOB | Hiroki Kuroda | At | SYI | Henderson Alvarez | |
| September | 8 | GOB | Adam Wainwright | At | SYI | Doug Fister | |
| September | 9 | GOB | Dan Haren | At | SYI | Yovani Gallardo | |
| September | 10 | NDF | Danny Salazar | At | SYI | Travis Wood* | |
| September | 11 | NDF | Matt Garza | At | SYI | Martin Perez* | |
| September | 12 | NDF | Wei-Ying Chen* | At | SYI | Hyun-Jin Ryu* | |
| September | 13 | SYI | Doug Fister | At | BUR | Danny Duffy* | |
| September | 14 | SYI | Henderson Alvarez | At | BUR | Matthew Moore* | |
| September | 15 | SYI | Travis Wood* | At | BUR | Jon Lester* | |
| September | OFF | ||||||
| September | 16 | + | SYI | Doug Fister | At | HUC | Derek Holland* |
| September | 17 | + | SYI | Yovani Gallardo | At | HUC | James Shields |
| September | 18 | + | SYI | Martin Perez* | At | HUC | Ian Kennedy |
| September | 19 | + | SYI | Travis Wood* | At | HUC | Corey Kluber |
| September | 20 | + | SYI | Henderson Alvarez | At | HUC | Hisashi Iwakuma |
| September | 21 | + | COL | Cliff Lee* | At | SYI | Doug Fister |
| September | 22 | + | COL | Ricky Nolasco | At | SYI | Yovani Gallardo |
| September | 23 | + | COL | Cole Hamels* | At | SYI | Hyun-Jin Ryu* |
| September | 24 | + | COL | Jarrod Parker | At | SYI | Travis Wood* |
| + Indicates In Division Game | |||||||