| Month | Game | + | Away | Pitcher | At | Home | Pitcher |
| September | 1 | SYI | Charlie Morton | At | CRC | Wade Miley* | |
| September | 2 | SYI | Jose Berrios | At | CRC | Matt Harvey | |
| September | 3 | SYI | German Marquez | At | CRC | Hyun-Jin Ryu* | |
| September | 4 | TAM | Luis Severino | At | SYI | Kendall Graveman | |
| September | 5 | TAM | Jason Hammel | At | SYI | Chase Anderson | |
| September | 6 | TAM | Kevin Gausman | At | SYI | Charlie Morton | |
| September | OFF | ||||||
| September | 7 | + | SYI | Jose Berrios | At | COL | Mike Montgomery* |
| September | 8 | + | SYI | German Marquez | At | COL | Clayton Kershaw* |
| September | 9 | + | SYI | Danny Duffy* | At | COL | Dylan Bundy |
| September | 10 | + | SYI | Kendall Graveman | At | COL | Cole Hamels* |
| September | 11 | + | SYI | James Paxton* | At | COL | Ervin Santana |
| September | 12 | + | WRK | Jimmy Nelson | At | SYI | Charlie Morton |
| September | 13 | + | WRK | Sean Manaea* | At | SYI | German Marquez |
| September | 14 | + | WRK | Jaime Garcia* | At | SYI | Danny Duffy* |
| September | 15 | + | WRK | Kyle Gibson | At | SYI | Kendall Graveman |
| September | OFF | ||||||
| September | 16 | SRD | Dallas Keuchel* | At | SYI | James Paxton* | |
| September | 17 | SRD | Francisco Liriano* | At | SYI | Charlie Morton | |
| September | 18 | SRD | Yu Darvish | At | SYI | German Marquez | |
| September | 19 | BUR | Lance McCullers | At | SYI | Chase Anderson | |
| September | 20 | BUR | Taijuan Walker | At | SYI | Jose Berrios | |
| September | 21 | BUR | Zack Greinke | At | SYI | James Paxton* | |
| September | 22 | SYI | Charlie Morton | At | OAK | Jharel Cotton | |
| September | 23 | SYI | Danny Duffy* | At | OAK | Eduardo Rodriguez* | |
| September | 24 | SYI | German Marquez | At | OAK | Nick Pivetta | |
| + Indicates In Division Game | |||||||