| 2022 Schedule | ||||||||||||
| Month | Game | #1 | #2 | #3 | #4 | #5 | #6 | #7 | #8 | #9 | #10 | Strat Date |
| March | 1 | SRD at COL | NYY at CUB | TAM at WRK | BUR at HOH | GGG at VRN | CRC at OAK | DYE at JAM | CWC at AAR | CHI at HUC | HMA at DUB | 4/7/2021 |
| March | 2 | SRD at COL | NYY at CUB | TAM at WRK | BUR at HOH | GGG at VRN | CRC at OAK | DYE at JAM | CWC at AAR | CHI at HUC | HMA at DUB | 4/8/2021 |
| March | 3 | SRD at COL | NYY at CUB | TAM at WRK | BUR at HOH | GGG at VRN | CRC at OAK | DYE at JAM | CWC at AAR | CHI at HUC | HMA at DUB | 4/9/2021 |
| March | OFF | 4/10/2021 | ||||||||||
| March | 4 | HUC at DUB | HMA at CHI | JAM at CRC | AAR at GGG | WRK at CWC | HOH at DYE | VRN at BUR | OAK at TAM | COL at CUB | NYY at SRD | 4/11/2021 |
| March | 5 | HUC at DUB | HMA at CHI | JAM at CRC | AAR at GGG | WRK at CWC | HOH at DYE | VRN at BUR | OAK at TAM | COL at CUB | NYY at SRD | 4/12/2021 |
| March | 6 | HUC at DUB | HMA at CHI | JAM at CRC | AAR at GGG | WRK at CWC | HOH at DYE | VRN at BUR | OAK at TAM | COL at CUB | NYY at SRD | 4/13/2021 |
| March | 7 | HUC at NYY | CUB at CHI | JAM at HOH | BUR at GGG | WRK at OAK | CRC at DYE | VRN at AAR | CWC at TAM | COL at HMA | DUB at SRD | 4/14/2021 |
| March | 8 | HUC at NYY | CUB at CHI | JAM at HOH | BUR at GGG | WRK at OAK | CRC at DYE | VRN at AAR | CWC at TAM | COL at HMA | DUB at SRD | 4/15/2021 |
| March | 9 | HUC at NYY | CUB at CHI | JAM at HOH | BUR at GGG | WRK at OAK | CRC at DYE | VRN at AAR | CWC at TAM | COL at HMA | DUB at SRD | 4/16/2021 |
| March | 10 | TAM at COL | NYY at BUR | DYE at WRK | HOH at CWC | SRD at VRN | OAK at CUB | JAM at CHI | AAR at DUB | GGG at HUC | HMA at CRC | 4/17/2021 |
| March | 11 | TAM at COL | NYY at BUR | DYE at WRK | HOH at CWC | SRD at VRN | OAK at CUB | JAM at CHI | AAR at DUB | GGG at HUC | HMA at CRC | 4/18/2021 |
| March | 12 | TAM at COL | NYY at BUR | DYE at WRK | HOH at CWC | SRD at VRN | OAK at CUB | JAM at CHI | AAR at DUB | GGG at HUC | HMA at CRC | 4/19/2021 |
| March | OFF | 4/20/2021 | ||||||||||
| March | 13 | DUB at JAM | CHI at AAR | CRC at VRN | OAK at GGG | CWC at HUC | HMA at DYE | COL at BUR | TAM at NYY | CUB at WRK | HOH at SRD | 4/21/2021 |
| March | 14 | DUB at JAM | CHI at AAR | CRC at VRN | OAK at GGG | CWC at HUC | HMA at DYE | COL at BUR | TAM at NYY | CUB at WRK | HOH at SRD | 4/22/2021 |
| March | 15 | DUB at JAM | CHI at AAR | CRC at VRN | OAK at GGG | CWC at HUC | HMA at DYE | COL at BUR | TAM at NYY | CUB at WRK | HOH at SRD | 4/23/2021 |
| March | 16 | NYY at JAM | CHI at BUR | VRN at HOH | GGG at CWC | HUC at OAK | DYE at CUB | AAR at COL | DUB at TAM | WRK at HMA | SRD at CRC | 4/24/2021 |
| March | 17 | NYY at JAM | CHI at BUR | VRN at HOH | GGG at CWC | HUC at OAK | DYE at CUB | AAR at COL | DUB at TAM | WRK at HMA | SRD at CRC | 4/25/2021 |
| March | 18 | NYY at JAM | CHI at BUR | VRN at HOH | GGG at CWC | HUC at OAK | DYE at CUB | AAR at COL | DUB at TAM | WRK at HMA | SRD at CRC | 4/26/2021 |
| March | 19 | DYE at COL | CWC at NYY | SRD at WRK | CUB at HOH | CHI at VRN | OAK at DUB | GGG at JAM | CRC at AAR | TAM at HUC | BUR at HMA | 4/27/2021 |
| March | 20 | DYE at COL | CWC at NYY | SRD at WRK | CUB at HOH | CHI at VRN | OAK at DUB | GGG at JAM | CRC at AAR | TAM at HUC | BUR at HMA | 4/28/2021 |
| March | 21 | DYE at COL | CWC at NYY | SRD at WRK | CUB at HOH | CHI at VRN | OAK at DUB | GGG at JAM | CRC at AAR | TAM at HUC | BUR at HMA | 4/29/2021 |
| April | 1 | VRN at DUB | OAK at CHI | HUC at CRC | HMA at GGG | COL at CWC | NYY at DYE | WRK at BUR | HOH at TAM | JAM at CUB | AAR at SRD | 4/30/2021 |
| April | 2 | VRN at DUB | OAK at CHI | HUC at CRC | HMA at GGG | COL at CWC | NYY at DYE | WRK at BUR | HOH at TAM | JAM at CUB | AAR at SRD | 5/1/2021 |
| April | 3 | VRN at DUB | OAK at CHI | HUC at CRC | HMA at GGG | COL at CWC | NYY at DYE | WRK at BUR | HOH at TAM | JAM at CUB | AAR at SRD | 5/2/2021 |
| April | OFF | 5/3/2021 | ||||||||||
| April | 4 | VRN at NYY | CWC at CHI | HUC at HOH | CUB at GGG | COL at OAK | DUB at DYE | WRK at AAR | CRC at TAM | JAM at HMA | BUR at SRD | 5/4/2021 |
| April | 5 | VRN at NYY | CWC at CHI | HUC at HOH | CUB at GGG | COL at OAK | DUB at DYE | WRK at AAR | CRC at TAM | JAM at HMA | BUR at SRD | 5/5/2021 |
| April | 6 | VRN at NYY | CWC at CHI | HUC at HOH | CUB at GGG | COL at OAK | DUB at DYE | WRK at AAR | CRC at TAM | JAM at HMA | BUR at SRD | 5/6/2021 |
| April | 7 | GGG at COL | NYY at CRC | CHI at WRK | HOH at DUB | TAM at VRN | BUR at OAK | SRD at JAM | AAR at CUB | DYE at HUC | HMA at CWC | 5/7/2021 |
| April | 8 | GGG at COL | NYY at CRC | CHI at WRK | HOH at DUB | TAM at VRN | BUR at OAK | SRD at JAM | AAR at CUB | DYE at HUC | HMA at CWC | 5/8/2021 |
| April | 9 | GGG at COL | NYY at CRC | CHI at WRK | HOH at DUB | TAM at VRN | BUR at OAK | SRD at JAM | AAR at CUB | DYE at HUC | HMA at CWC | 5/9/2021 |
| April | 10 | DUB at WRK | CHI at HOH | COL at CRC | NYY at GGG | JAM at CWC | AAR at DYE | BUR at HUC | HMA at TAM | CUB at VRN | SRD at OAK | 5/10/2021 |
| April | 11 | DUB at WRK | CHI at HOH | COL at CRC | NYY at GGG | JAM at CWC | AAR at DYE | BUR at HUC | HMA at TAM | CUB at VRN | SRD at OAK | 5/11/2021 |
| April | 12 | DUB at WRK | CHI at HOH | COL at CRC | NYY at GGG | JAM at CWC | AAR at DYE | BUR at HUC | HMA at TAM | CUB at VRN | SRD at OAK | 5/12/2021 |
| April | OFF | 5/13/2021 | ||||||||||
| April | 13 | WRK at NYY | CRC at CHI | HOH at COL | GGG at DUB | OAK at JAM | DYE at BUR | HUC at AAR | TAM at CUB | VRN at HMA | CWC at SRD | 5/14/2021 |
| April | 14 | WRK at NYY | CRC at CHI | HOH at COL | GGG at DUB | OAK at JAM | DYE at BUR | HUC at AAR | TAM at CUB | VRN at HMA | CWC at SRD | 5/15/2021 |
| April | 15 | WRK at NYY | CRC at CHI | HOH at COL | GGG at DUB | OAK at JAM | DYE at BUR | HUC at AAR | TAM at CUB | VRN at HMA | CWC at SRD | 5/16/2021 |
| April | 16 | COL at SRD | CUB at NYY | WRK at TAM | HOH at BUR | VRN at GGG | OAK at CRC | JAM at DYE | AAR at CWC | HUC at CHI | DUB at HMA | 5/17/2021 |
| April | 17 | COL at SRD | CUB at NYY | WRK at TAM | HOH at BUR | VRN at GGG | OAK at CRC | JAM at DYE | AAR at CWC | HUC at CHI | DUB at HMA | 5/18/2021 |
| April | 18 | COL at SRD | CUB at NYY | WRK at TAM | HOH at BUR | VRN at GGG | OAK at CRC | JAM at DYE | AAR at CWC | HUC at CHI | DUB at HMA | 5/19/2021 |
| April | 19 | DUB at HUC | CHI at HMA | CRC at JAM | GGG at AAR | CWC at WRK | DYE at HOH | BUR at VRN | TAM at OAK | CUB at COL | SRD at NYY | 5/20/2021 |
| April | 20 | DUB at HUC | CHI at HMA | CRC at JAM | GGG at AAR | CWC at WRK | DYE at HOH | BUR at VRN | TAM at OAK | CUB at COL | SRD at NYY | 5/21/2021 |
| April | 21 | DUB at HUC | CHI at HMA | CRC at JAM | GGG at AAR | CWC at WRK | DYE at HOH | BUR at VRN | TAM at OAK | CUB at COL | SRD at NYY | 5/22/2021 |
| May | 1 | NYY at HUC | CHI at CUB | HOH at JAM | GGG at BUR | OAK at WRK | DYE at CRC | AAR at VRN | TAM at CWC | HMA at COL | SRD at DUB | 5/23/2021 |
| May | 2 | NYY at HUC | CHI at CUB | HOH at JAM | GGG at BUR | OAK at WRK | DYE at CRC | AAR at VRN | TAM at CWC | HMA at COL | SRD at DUB | 5/24/2021 |
| May | 3 | NYY at HUC | CHI at CUB | HOH at JAM | GGG at BUR | OAK at WRK | DYE at CRC | AAR at VRN | TAM at CWC | HMA at COL | SRD at DUB | 5/25/2021 |
| May | OFF | 5/26/2021 | ||||||||||
| May | 4 | * VRN at WRK | * JAM at HUC | * OAK at HOH | * AAR at HMA | * CWC at CRC | * BUR at CUB | * DYE at GGG | * TAM at SRD | COL at NYY | DUB at CHI | 5/27/2021 |
| May | 5 | * VRN at WRK | * JAM at HUC | * OAK at HOH | * AAR at HMA | * CWC at CRC | * BUR at CUB | * DYE at GGG | * TAM at SRD | COL at NYY | DUB at CHI | 5/28/2021 |
| May | 6 | * VRN at WRK | * JAM at HUC | * OAK at HOH | * AAR at HMA | * CWC at CRC | * BUR at CUB | * DYE at GGG | * TAM at SRD | COL at NYY | DUB at CHI | 5/29/2021 |
| May | 7 | * VRN at WRK | * JAM at HUC | * OAK at HOH | * AAR at HMA | * CWC at CRC | * BUR at CUB | * DYE at GGG | * TAM at SRD | COL at DUB | NYY at CHI | 5/30/2021 |
| May | 8 | * VRN at WRK | * JAM at HUC | * OAK at HOH | * AAR at HMA | * CWC at CRC | * BUR at CUB | * DYE at GGG | * TAM at SRD | COL at DUB | NYY at CHI | 5/31/2021 |
| May | 9 | * WRK at JAM | * HUC at VRN | * HOH at AAR | * HMA at OAK | * CRC at BUR | * CUB at CWC | * GGG at TAM | * SRD at DYE | COL at DUB | NYY at CHI | 6/1/2021 |
| May | 10 | * WRK at JAM | * HUC at VRN | * HOH at AAR | * HMA at OAK | * CRC at BUR | * CUB at CWC | * GGG at TAM | * SRD at DYE | CHI at COL | DUB at NYY | 6/2/2021 |
| May | 11 | * WRK at JAM | * HUC at VRN | * HOH at AAR | * HMA at OAK | * CRC at BUR | * CUB at CWC | * GGG at TAM | * SRD at DYE | CHI at COL | DUB at NYY | 6/3/2021 |
| May | 12 | * WRK at JAM | * HUC at VRN | * HOH at AAR | * HMA at OAK | * CRC at BUR | * CUB at CWC | * GGG at TAM | * SRD at DYE | CHI at COL | DUB at NYY | 6/4/2021 |
| May | OFF | 6/5/2021 | ||||||||||
| May | 13 | * JAM at VRN | * HUC at COL | * AAR at OAK | * HMA at NYY | * BUR at CWC | * CUB at DUB | * TAM at DYE | * SRD at CHI | WRK at HOH | CRC at GGG | 6/6/2021 |
| May | 14 | * JAM at VRN | * HUC at COL | * AAR at OAK | * HMA at NYY | * BUR at CWC | * CUB at DUB | * TAM at DYE | * SRD at CHI | WRK at HOH | CRC at GGG | 6/7/2021 |
| May | 15 | * JAM at VRN | * HUC at COL | * AAR at OAK | * HMA at NYY | * BUR at CWC | * CUB at DUB | * TAM at DYE | * SRD at CHI | WRK at HOH | CRC at GGG | 6/8/2021 |
| May | 16 | * JAM at VRN | * HUC at COL | * AAR at OAK | * HMA at NYY | * BUR at CWC | * CUB at DUB | * TAM at DYE | * SRD at CHI | WRK at CRC | HOH at GGG | 6/9/2021 |
| May | 17 | * JAM at VRN | * HUC at COL | * AAR at OAK | * HMA at NYY | * BUR at CWC | * CUB at DUB | * TAM at DYE | * SRD at CHI | WRK at CRC | HOH at GGG | 6/10/2021 |
| May | 18 | * VRN at HUC | * COL at JAM | * OAK at HMA | * NYY at AAR | * CWC at CUB | * DUB at BUR | * DYE at SRD | * CHI at TAM | WRK at CRC | HOH at GGG | 6/11/2021 |
| May | 19 | * VRN at HUC | * COL at JAM | * OAK at HMA | * NYY at AAR | * CWC at CUB | * DUB at BUR | * DYE at SRD | * CHI at TAM | GGG at WRK | CRC at HOH | 6/12/2021 |
| May | 20 | * VRN at HUC | * COL at JAM | * OAK at HMA | * NYY at AAR | * CWC at CUB | * DUB at BUR | * DYE at SRD | * CHI at TAM | GGG at WRK | CRC at HOH | 6/13/2021 |
| May | 21 | * VRN at HUC | * COL at JAM | * OAK at HMA | * NYY at AAR | * CWC at CUB | * DUB at BUR | * DYE at SRD | * CHI at TAM | GGG at WRK | CRC at HOH | 6/14/2021 |
| May | OFF | 6/15/2021 | ||||||||||
| May | 22 | COL at TAM | BUR at NYY | WRK at DYE | CWC at HOH | VRN at SRD | CUB at OAK | CHI at JAM | DUB at AAR | HUC at GGG | CRC at HMA | 6/16/2021 |
| May | 23 | COL at TAM | BUR at NYY | WRK at DYE | CWC at HOH | VRN at SRD | CUB at OAK | CHI at JAM | DUB at AAR | HUC at GGG | CRC at HMA | 6/17/2021 |
| May | 24 | COL at TAM | BUR at NYY | WRK at DYE | CWC at HOH | VRN at SRD | CUB at OAK | CHI at JAM | DUB at AAR | HUC at GGG | CRC at HMA | 6/18/2021 |
| June | 1 | JAM at DUB | AAR at CHI | VRN at CRC | GGG at OAK | HUC at CWC | DYE at HMA | BUR at COL | NYY at TAM | WRK at CUB | SRD at HOH | 6/19/2021 |
| June | 2 | JAM at DUB | AAR at CHI | VRN at CRC | GGG at OAK | HUC at CWC | DYE at HMA | BUR at COL | NYY at TAM | WRK at CUB | SRD at HOH | 6/20/2021 |
| June | 3 | JAM at DUB | AAR at CHI | VRN at CRC | GGG at OAK | HUC at CWC | DYE at HMA | BUR at COL | NYY at TAM | WRK at CUB | SRD at HOH | 6/21/2021 |
| June | 4 | JAM at NYY | BUR at CHI | HOH at VRN | CWC at GGG | OAK at HUC | CUB at DYE | COL at AAR | TAM at DUB | HMA at WRK | CRC at SRD | 6/22/2021 |
| June | 5 | JAM at NYY | BUR at CHI | HOH at VRN | CWC at GGG | OAK at HUC | CUB at DYE | COL at AAR | TAM at DUB | HMA at WRK | CRC at SRD | 6/23/2021 |
| June | 6 | JAM at NYY | BUR at CHI | HOH at VRN | CWC at GGG | OAK at HUC | CUB at DYE | COL at AAR | TAM at DUB | HMA at WRK | CRC at SRD | 6/24/2021 |
| June | OFF | 6/25/2021 | ||||||||||
| June | 7 | * COL at HUC | * WRK at VRN | * NYY at HMA | * HOH at OAK | * DUB at CUB | * CRC at CWC | * CHI at SRD | * GGG at DYE | JAM at AAR | TAM at BUR | 6/26/2021 |
| June | 8 | * COL at HUC | * WRK at VRN | * NYY at HMA | * HOH at OAK | * DUB at CUB | * CRC at CWC | * CHI at SRD | * GGG at DYE | JAM at AAR | TAM at BUR | 6/27/2021 |
| June | 9 | * COL at HUC | * WRK at VRN | * NYY at HMA | * HOH at OAK | * DUB at CUB | * CRC at CWC | * CHI at SRD | * GGG at DYE | JAM at AAR | TAM at BUR | 6/28/2021 |
| June | 10 | * COL at HUC | * WRK at VRN | * NYY at HMA | * HOH at OAK | * DUB at CUB | * CRC at CWC | * CHI at SRD | * GGG at DYE | BUR at JAM | AAR at TAM | 6/29/2021 |
| June | 11 | * COL at HUC | * WRK at VRN | * NYY at HMA | * HOH at OAK | * DUB at CUB | * CRC at CWC | * CHI at SRD | * GGG at DYE | BUR at JAM | AAR at TAM | 6/30/2021 |
| June | 12 | * HUC at WRK | * VRN at COL | * HMA at HOH | * OAK at NYY | * CUB at CRC | * CWC at DUB | * SRD at GGG | * DYE at CHI | BUR at JAM | AAR at TAM | 7/1/2021 |
| June | 13 | * HUC at WRK | * VRN at COL | * HMA at HOH | * OAK at NYY | * CUB at CRC | * CWC at DUB | * SRD at GGG | * DYE at CHI | TAM at JAM | AAR at BUR | 7/2/2021 |
| June | 14 | * HUC at WRK | * VRN at COL | * HMA at HOH | * OAK at NYY | * CUB at CRC | * CWC at DUB | * SRD at GGG | * DYE at CHI | TAM at JAM | AAR at BUR | 7/3/2021 |
| June | 15 | * HUC at WRK | * VRN at COL | * HMA at HOH | * OAK at NYY | * CUB at CRC | * CWC at DUB | * SRD at GGG | * DYE at CHI | TAM at JAM | AAR at BUR | 7/4/2021 |
| June | OFF | 7/5/2021 | ||||||||||
| June | 16 | * HUC at JAM | * COL at WRK | * HMA at AAR | * NYY at HOH | * CUB at BUR | * DUB at CRC | * SRD at TAM | * CHI at GGG | OAK at VRN | DYE at CWC | 7/6/2021 |
| June | 17 | * HUC at JAM | * COL at WRK | * HMA at AAR | * NYY at HOH | * CUB at BUR | * DUB at CRC | * SRD at TAM | * CHI at GGG | OAK at VRN | DYE at CWC | 7/7/2021 |
| June | 18 | * HUC at JAM | * COL at WRK | * HMA at AAR | * NYY at HOH | * CUB at BUR | * DUB at CRC | * SRD at TAM | * CHI at GGG | OAK at VRN | DYE at CWC | 7/8/2021 |
| June | 19 | * HUC at JAM | * COL at WRK | * HMA at AAR | * NYY at HOH | * CUB at BUR | * DUB at CRC | * SRD at TAM | * CHI at GGG | CWC at VRN | DYE at OAK | 7/9/2021 |
| June | 20 | * HUC at JAM | * COL at WRK | * HMA at AAR | * NYY at HOH | * CUB at BUR | * DUB at CRC | * SRD at TAM | * CHI at GGG | CWC at VRN | DYE at OAK | 7/10/2021 |
| June | 21 | * JAM at COL | * WRK at HUC | * AAR at NYY | * HOH at HMA | * BUR at DUB | * CRC at CUB | * TAM at CHI | * GGG at SRD | CWC at VRN | DYE at OAK | 7/11/2021 |
| June | 22 | * JAM at COL | * WRK at HUC | * AAR at NYY | * HOH at HMA | * BUR at DUB | * CRC at CUB | * TAM at CHI | * GGG at SRD | VRN at DYE | OAK at CWC | 7/12/2021 |
| June | 23 | * JAM at COL | * WRK at HUC | * AAR at NYY | * HOH at HMA | * BUR at DUB | * CRC at CUB | * TAM at CHI | * GGG at SRD | VRN at DYE | OAK at CWC | 7/13/2021 |
| June | 24 | * JAM at COL | * WRK at HUC | * AAR at NYY | * HOH at HMA | * BUR at DUB | * CRC at CUB | * TAM at CHI | * GGG at SRD | VRN at DYE | OAK at CWC | 7/14/2021 |
| All Star Break | OFF | 7/15/2021 | ||||||||||
| All Star Break | OFF | 7/16/2021 | ||||||||||
| All Star Break | OFF | 7/17/2021 | ||||||||||
| July | 1 | COL at DYE | NYY at CWC | WRK at SRD | HOH at CUB | VRN at CHI | DUB at OAK | JAM at GGG | AAR at CRC | HUC at TAM | HMA at BUR | 7/18/2021 |
| July | 2 | COL at DYE | NYY at CWC | WRK at SRD | HOH at CUB | VRN at CHI | DUB at OAK | JAM at GGG | AAR at CRC | HUC at TAM | HMA at BUR | 7/19/2021 |
| July | 3 | COL at DYE | NYY at CWC | WRK at SRD | HOH at CUB | VRN at CHI | DUB at OAK | JAM at GGG | AAR at CRC | HUC at TAM | HMA at BUR | 7/20/2021 |
| July | 4 | DUB at VRN | CHI at OAK | CRC at HUC | GGG at HMA | CWC at COL | DYE at NYY | BUR at WRK | TAM at HOH | CUB at JAM | SRD at AAR | 7/21/2021 |
| July | 5 | DUB at VRN | CHI at OAK | CRC at HUC | GGG at HMA | CWC at COL | DYE at NYY | BUR at WRK | TAM at HOH | CUB at JAM | SRD at AAR | 7/22/2021 |
| July | 6 | DUB at VRN | CHI at OAK | CRC at HUC | GGG at HMA | CWC at COL | DYE at NYY | BUR at WRK | TAM at HOH | CUB at JAM | SRD at AAR | 7/23/2021 |
| July | OFF | 7/24/2021 | ||||||||||
| July | 7 | * JAM at WRK | * VRN at HUC | * AAR at HOH | * OAK at HMA | * BUR at CRC | * CWC at CUB | * TAM at GGG | * DYE at SRD | NYY at COL | CHI at DUB | 7/25/2021 |
| July | 8 | * JAM at WRK | * VRN at HUC | * AAR at HOH | * OAK at HMA | * BUR at CRC | * CWC at CUB | * TAM at GGG | * DYE at SRD | NYY at COL | CHI at DUB | 7/26/2021 |
| July | 9 | * JAM at WRK | * VRN at HUC | * AAR at HOH | * OAK at HMA | * BUR at CRC | * CWC at CUB | * TAM at GGG | * DYE at SRD | NYY at COL | CHI at DUB | 7/27/2021 |
| July | 10 | * JAM at WRK | * VRN at HUC | * AAR at HOH | * OAK at HMA | * BUR at CRC | * CWC at CUB | * TAM at GGG | * DYE at SRD | DUB at COL | CHI at NYY | 7/28/2021 |
| July | 11 | * JAM at WRK | * VRN at HUC | * AAR at HOH | * OAK at HMA | * BUR at CRC | * CWC at CUB | * TAM at GGG | * DYE at SRD | DUB at COL | CHI at NYY | 7/29/2021 |
| July | 12 | * WRK at VRN | * HUC at JAM | * HOH at OAK | * HMA at AAR | * CRC at CWC | * CUB at BUR | * GGG at DYE | * SRD at TAM | DUB at COL | CHI at NYY | 7/30/2021 |
| July | 13 | * WRK at VRN | * HUC at JAM | * HOH at OAK | * HMA at AAR | * CRC at CWC | * CUB at BUR | * GGG at DYE | * SRD at TAM | COL at CHI | NYY at DUB | 7/31/2021 |
| July | 14 | * WRK at VRN | * HUC at JAM | * HOH at OAK | * HMA at AAR | * CRC at CWC | * CUB at BUR | * GGG at DYE | * SRD at TAM | COL at CHI | NYY at DUB | 8/1/2021 |
| July | 15 | * WRK at VRN | * HUC at JAM | * HOH at OAK | * HMA at AAR | * CRC at CWC | * CUB at BUR | * GGG at DYE | * SRD at TAM | COL at CHI | NYY at DUB | 8/2/2021 |
| July | OFF | 8/3/2021 | ||||||||||
| July | 16 | * WRK at COL | * VRN at JAM | * HOH at NYY | * OAK at AAR | * CRC at DUB | * CWC at BUR | * GGG at CHI | * DYE at TAM | HUC at HMA | CUB at SRD | 8/4/2021 |
| July | 17 | * WRK at COL | * VRN at JAM | * HOH at NYY | * OAK at AAR | * CRC at DUB | * CWC at BUR | * GGG at CHI | * DYE at TAM | HUC at HMA | CUB at SRD | 8/5/2021 |
| July | 18 | * WRK at COL | * VRN at JAM | * HOH at NYY | * OAK at AAR | * CRC at DUB | * CWC at BUR | * GGG at CHI | * DYE at TAM | HUC at HMA | CUB at SRD | 8/6/2021 |
| July | 19 | * WRK at COL | * VRN at JAM | * HOH at NYY | * OAK at AAR | * CRC at DUB | * CWC at BUR | * GGG at CHI | * DYE at TAM | HUC at CUB | HMA at SRD | 8/7/2021 |
| July | 20 | * WRK at COL | * VRN at JAM | * HOH at NYY | * OAK at AAR | * CRC at DUB | * CWC at BUR | * GGG at CHI | * DYE at TAM | HUC at CUB | HMA at SRD | 8/8/2021 |
| July | 21 | * COL at VRN | * JAM at WRK | * NYY at OAK | * AAR at HOH | * DUB at CWC | * BUR at CRC | * CHI at DYE | * TAM at GGG | HUC at CUB | HMA at SRD | 8/9/2021 |
| July | 22 | * COL at VRN | * JAM at WRK | * NYY at OAK | * AAR at HOH | * DUB at CWC | * BUR at CRC | * CHI at DYE | * TAM at GGG | SRD at HUC | CUB at HMA | 8/10/2021 |
| July | 23 | * COL at VRN | * JAM at WRK | * NYY at OAK | * AAR at HOH | * DUB at CWC | * BUR at CRC | * CHI at DYE | * TAM at GGG | SRD at HUC | CUB at HMA | 8/11/2021 |
| July | 24 | * COL at VRN | * JAM at WRK | * NYY at OAK | * AAR at HOH | * DUB at CWC | * BUR at CRC | * CHI at DYE | * TAM at GGG | SRD at HUC | CUB at HMA | 8/12/2021 |
| Trade Deadline | OFF | 8/13/2021 | ||||||||||
| August | 1 | NYY at VRN | CHI at CWC | HOH at HUC | GGG at CUB | OAK at COL | DYE at DUB | AAR at WRK | TAM at CRC | HMA at JAM | SRD at BUR | 8/14/2021 |
| August | 2 | NYY at VRN | CHI at CWC | HOH at HUC | GGG at CUB | OAK at COL | DYE at DUB | AAR at WRK | TAM at CRC | HMA at JAM | SRD at BUR | 8/15/2021 |
| August | 3 | NYY at VRN | CHI at CWC | HOH at HUC | GGG at CUB | OAK at COL | DYE at DUB | AAR at WRK | TAM at CRC | HMA at JAM | SRD at BUR | 8/16/2021 |
| August | 4 | COL at GGG | CRC at NYY | WRK at CHI | DUB at HOH | VRN at TAM | OAK at BUR | JAM at SRD | CUB at AAR | HUC at DYE | CWC at HMA | 8/17/2021 |
| August | 5 | COL at GGG | CRC at NYY | WRK at CHI | DUB at HOH | VRN at TAM | OAK at BUR | JAM at SRD | CUB at AAR | HUC at DYE | CWC at HMA | 8/18/2021 |
| August | 6 | COL at GGG | CRC at NYY | WRK at CHI | DUB at HOH | VRN at TAM | OAK at BUR | JAM at SRD | CUB at AAR | HUC at DYE | CWC at HMA | 8/19/2021 |
| August | OFF | 8/20/2021 | ||||||||||
| August | 7 | * HUC at VRN | * JAM at COL | * HMA at OAK | * AAR at NYY | * CUB at CWC | * BUR at DUB | * SRD at DYE | * TAM at CHI | HOH at WRK | GGG at CRC | 8/21/2021 |
| August | 8 | * HUC at VRN | * JAM at COL | * HMA at OAK | * AAR at NYY | * CUB at CWC | * BUR at DUB | * SRD at DYE | * TAM at CHI | HOH at WRK | GGG at CRC | 8/22/2021 |
| August | 9 | * HUC at VRN | * JAM at COL | * HMA at OAK | * AAR at NYY | * CUB at CWC | * BUR at DUB | * SRD at DYE | * TAM at CHI | HOH at WRK | GGG at CRC | 8/23/2021 |
| August | 10 | * HUC at VRN | * JAM at COL | * HMA at OAK | * AAR at NYY | * CUB at CWC | * BUR at DUB | * SRD at DYE | * TAM at CHI | CRC at WRK | GGG at HOH | 8/24/2021 |
| August | 11 | * HUC at VRN | * JAM at COL | * HMA at OAK | * AAR at NYY | * CUB at CWC | * BUR at DUB | * SRD at DYE | * TAM at CHI | CRC at WRK | GGG at HOH | 8/25/2021 |
| August | 12 | * VRN at JAM | * COL at HUC | * OAK at AAR | * NYY at HMA | * CWC at BUR | * DUB at CUB | * DYE at TAM | * CHI at SRD | CRC at WRK | GGG at HOH | 8/26/2021 |
| August | 13 | * VRN at JAM | * COL at HUC | * OAK at AAR | * NYY at HMA | * CWC at BUR | * DUB at CUB | * DYE at TAM | * CHI at SRD | WRK at GGG | HOH at CRC | 8/27/2021 |
| August | 14 | * VRN at JAM | * COL at HUC | * OAK at AAR | * NYY at HMA | * CWC at BUR | * DUB at CUB | * DYE at TAM | * CHI at SRD | WRK at GGG | HOH at CRC | 8/28/2021 |
| August | 15 | * VRN at JAM | * COL at HUC | * OAK at AAR | * NYY at HMA | * CWC at BUR | * DUB at CUB | * DYE at TAM | * CHI at SRD | WRK at GGG | HOH at CRC | 8/29/2021 |
| August | OFF | 8/30/2021 | ||||||||||
| August | 16 | * WRK at HUC | * COL at VRN | * HOH at HMA | * NYY at OAK | * CRC at CUB | * DUB at CWC | * GGG at SRD | * CHI at DYE | AAR at JAM | BUR at TAM | 8/31/2021 |
| August | 17 | * WRK at HUC | * COL at VRN | * HOH at HMA | * NYY at OAK | * CRC at CUB | * DUB at CWC | * GGG at SRD | * CHI at DYE | AAR at JAM | BUR at TAM | 9/1/2021 |
| August | 18 | * WRK at HUC | * COL at VRN | * HOH at HMA | * NYY at OAK | * CRC at CUB | * DUB at CWC | * GGG at SRD | * CHI at DYE | AAR at JAM | BUR at TAM | 9/2/2021 |
| August | 19 | * WRK at HUC | * COL at VRN | * HOH at HMA | * NYY at OAK | * CRC at CUB | * DUB at CWC | * GGG at SRD | * CHI at DYE | JAM at BUR | TAM at AAR | 9/3/2021 |
| August | 20 | * WRK at HUC | * COL at VRN | * HOH at HMA | * NYY at OAK | * CRC at CUB | * DUB at CWC | * GGG at SRD | * CHI at DYE | JAM at BUR | TAM at AAR | 9/4/2021 |
| August | 21 | * HUC at COL | * VRN at WRK | * HMA at NYY | * OAK at HOH | * CUB at DUB | * CWC at CRC | * SRD at CHI | * DYE at GGG | JAM at BUR | TAM at AAR | 9/5/2021 |
| August | 22 | * HUC at COL | * VRN at WRK | * HMA at NYY | * OAK at HOH | * CUB at DUB | * CWC at CRC | * SRD at CHI | * DYE at GGG | JAM at TAM | BUR at AAR | 9/6/2021 |
| August | 23 | * HUC at COL | * VRN at WRK | * HMA at NYY | * OAK at HOH | * CUB at DUB | * CWC at CRC | * SRD at CHI | * DYE at GGG | JAM at TAM | BUR at AAR | 9/7/2021 |
| August | 24 | * HUC at COL | * VRN at WRK | * HMA at NYY | * OAK at HOH | * CUB at DUB | * CWC at CRC | * SRD at CHI | * DYE at GGG | JAM at TAM | BUR at AAR | 9/8/2021 |
| September | 1 | WRK at DUB | HOH at CHI | CRC at COL | GGG at NYY | CWC at JAM | DYE at AAR | HUC at BUR | TAM at HMA | VRN at CUB | OAK at SRD | 9/9/2021 |
| September | 2 | WRK at DUB | HOH at CHI | CRC at COL | GGG at NYY | CWC at JAM | DYE at AAR | HUC at BUR | TAM at HMA | VRN at CUB | OAK at SRD | 9/10/2021 |
| September | 3 | WRK at DUB | HOH at CHI | CRC at COL | GGG at NYY | CWC at JAM | DYE at AAR | HUC at BUR | TAM at HMA | VRN at CUB | OAK at SRD | 9/11/2021 |
| September | 4 | NYY at WRK | CHI at CRC | COL at HOH | DUB at GGG | JAM at OAK | BUR at DYE | AAR at HUC | CUB at TAM | HMA at VRN | SRD at CWC | 9/12/2021 |
| September | 5 | NYY at WRK | CHI at CRC | COL at HOH | DUB at GGG | JAM at OAK | BUR at DYE | AAR at HUC | CUB at TAM | HMA at VRN | SRD at CWC | 9/13/2021 |
| September | 6 | NYY at WRK | CHI at CRC | COL at HOH | DUB at GGG | JAM at OAK | BUR at DYE | AAR at HUC | CUB at TAM | HMA at VRN | SRD at CWC | 9/14/2021 |
| September | OFF | 9/15/2021 | ||||||||||
| September | 7 | * COL at JAM | * HUC at WRK | * NYY at AAR | * HMA at HOH | * DUB at BUR | * CUB at CRC | * CHI at TAM | * SRD at GGG | VRN at OAK | CWC at DYE | 9/16/2021 |
| September | 8 | * COL at JAM | * HUC at WRK | * NYY at AAR | * HMA at HOH | * DUB at BUR | * CUB at CRC | * CHI at TAM | * SRD at GGG | VRN at OAK | CWC at DYE | 9/17/2021 |
| September | 9 | * COL at JAM | * HUC at WRK | * NYY at AAR | * HMA at HOH | * DUB at BUR | * CUB at CRC | * CHI at TAM | * SRD at GGG | VRN at OAK | CWC at DYE | 9/18/2021 |
| September | 10 | * COL at JAM | * HUC at WRK | * NYY at AAR | * HMA at HOH | * DUB at BUR | * CUB at CRC | * CHI at TAM | * SRD at GGG | VRN at CWC | OAK at DYE | 9/19/2021 |
| September | 11 | * COL at JAM | * HUC at WRK | * NYY at AAR | * HMA at HOH | * DUB at BUR | * CUB at CRC | * CHI at TAM | * SRD at GGG | VRN at CWC | OAK at DYE | 9/20/2021 |
| September | 12 | * JAM at HUC | * WRK at COL | * AAR at HMA | * HOH at NYY | * BUR at CUB | * CRC at DUB | * TAM at SRD | * GGG at CHI | VRN at CWC | OAK at DYE | 9/21/2021 |
| September | 13 | * JAM at HUC | * WRK at COL | * AAR at HMA | * HOH at NYY | * BUR at CUB | * CRC at DUB | * TAM at SRD | * GGG at CHI | DYE at VRN | CWC at OAK | 9/22/2021 |
| September | 14 | * JAM at HUC | * WRK at COL | * AAR at HMA | * HOH at NYY | * BUR at CUB | * CRC at DUB | * TAM at SRD | * GGG at CHI | DYE at VRN | CWC at OAK | 9/23/2021 |
| September | 15 | * JAM at HUC | * WRK at COL | * AAR at HMA | * HOH at NYY | * BUR at CUB | * CRC at DUB | * TAM at SRD | * GGG at CHI | DYE at VRN | CWC at OAK | 9/24/2021 |
| September | OFF | 9/25/2021 | ||||||||||
| September | 16 | * VRN at COL | * WRK at JAM | * OAK at NYY | * HOH at AAR | * CWC at DUB | * CRC at BUR | * DYE at CHI | * GGG at TAM | HMA at HUC | SRD at CUB | 9/26/2021 |
| September | 17 | * VRN at COL | * WRK at JAM | * OAK at NYY | * HOH at AAR | * CWC at DUB | * CRC at BUR | * DYE at CHI | * GGG at TAM | HMA at HUC | SRD at CUB | 9/27/2021 |
| September | 18 | * VRN at COL | * WRK at JAM | * OAK at NYY | * HOH at AAR | * CWC at DUB | * CRC at BUR | * DYE at CHI | * GGG at TAM | HMA at HUC | SRD at CUB | 9/28/2021 |
| September | 19 | * VRN at COL | * WRK at JAM | * OAK at NYY | * HOH at AAR | * CWC at DUB | * CRC at BUR | * DYE at CHI | * GGG at TAM | CUB at HUC | SRD at HMA | 9/29/2021 |
| September | 20 | * VRN at COL | * WRK at JAM | * OAK at NYY | * HOH at AAR | * CWC at DUB | * CRC at BUR | * DYE at CHI | * GGG at TAM | CUB at HUC | SRD at HMA | 9/30/2021 |
| September | 21 | * COL at WRK | * JAM at VRN | * NYY at HOH | * AAR at OAK | * DUB at CRC | * BUR at CWC | * CHI at GGG | * TAM at DYE | CUB at HUC | SRD at HMA | 10/1/2021 |
| September | 22 | * COL at WRK | * JAM at VRN | * NYY at HOH | * AAR at OAK | * DUB at CRC | * BUR at CWC | * CHI at GGG | * TAM at DYE | HUC at SRD | HMA at CUB | 10/2/2021 |
| September | 23 | * COL at WRK | * JAM at VRN | * NYY at HOH | * AAR at OAK | * DUB at CRC | * BUR at CWC | * CHI at GGG | * TAM at DYE | HUC at SRD | HMA at CUB | 10/3/2021 |
| September | 24 | * COL at WRK | * JAM at VRN | * NYY at HOH | * AAR at OAK | * DUB at CRC | * BUR at CWC | * CHI at GGG | * TAM at DYE | HUC at SRD | HMA at CUB | 10/4/2021 |