| Month | Game | Strat Date | + | Away | Pitcher | Balance | At | Home | Pitcher | Balance |
| March | 1 | 3/27/2025 | CHI | Spencer Schwellenbach | 3R | At | VRN | Sandy Alcantara | 1L | |
| March | 2 | 3/28/2025 | CHI | Aaron Civale | E | At | VRN | Yusei Kikuchi* | 2L | |
| March | 3 | 3/29/2025 | CHI | Nick Martinez | 2L | At | VRN | Will Warren | 2R | |
| March | OFF | 3/30/2025 | ||||||||
| March | 4 | 3/31/2025 | CHI | Dean Kremer | 1R | At | DUB | Matthew Liberatore* | 1R | |
| March | 5 | 4/1/2025 | CHI | Noah Cameron* | 2L | At | DUB | Jose Quintana* | 1R | |
| March | 6 | 4/2/2025 | CHI | Spencer Schwellenbach | 3R | At | DUB | Andrew Abbott* | E | |
| March | 7 | 4/3/2025 | NYY | Luis Castillo | 6R | At | CHI | Aaron Civale | E | |
| March | 8 | 4/4/2025 | NYY | Jack Leiter | 5L | At | CHI | Nick Martinez | 2L | |
| March | 9 | 4/5/2025 | NYY | Clay Holmes | 1L | At | CHI | Dean Kremer | 1R | |
| March | 10 | 4/6/2025 | CHI | Noah Cameron* | 2L | At | NIM | Jameson Taillon | 7L | |
| March | 11 | 4/7/2025 | CHI | Spencer Schwellenbach | 3R | At | NIM | Matt Boyd* | 3L | |
| March | 12 | 4/8/2025 | CHI | Aaron Civale | E | At | NIM | Dylan Cease | E | |
| March | OFF | 4/9/2025 | ||||||||
| March | 13 | 4/10/2025 | CUB | Edward Cabrera | 1R | At | CHI | Nick Martinez | 2L | |
| March | 14 | 4/11/2025 | CUB | Mackenzie Gore* | 2L | At | CHI | Dean Kremer | 1R | |
| March | 15 | 4/12/2025 | CUB | Kyle Hendricks | 4L | At | CHI | Noah Cameron* | 2L | |
| March | 16 | 4/13/2025 | CHI | Spencer Schwellenbach | 3R | At | HMA | Carlos Rodon* | E | |
| March | 17 | 4/14/2025 | CHI | Aaron Civale | E | At | HMA | Jesus Luzardo* | 5L | |
| March | 18 | 4/15/2025 | CHI | Nick Martinez | 2L | At | HMA | Merrill Kelly | 1R | |
| March | 19 | 4/16/2025 | COL | Tarik Skubal* | E | At | CHI | Dean Kremer | 1R | |
| March | 20 | 4/17/2025 | COL | Freddy Peralta | E | At | CHI | Noah Cameron* | 2L | |
| March | 21 | 4/18/2025 | COL | Zac Gallen | E | At | CHI | Spencer Schwellenbach | 3R | |
| + Indicates In Division Game | ||||||||||