| Month | Game | Strat Date | + | Away | Pitcher | Balance | At | Home | Pitcher | Balance |
| March | 1 | 3/27/2025 | COL | Emmet Sheehan | 2L | At | SRD | Kyle Freeland* | 3L | |
| March | 2 | 3/28/2025 | COL | Tarik Skubal* | E | At | SRD | Robbie Ray* | 3L | |
| March | 3 | 3/29/2025 | COL | J.T. Ginn | 9R | At | SRD | Chris Sale* | 3L | |
| March | OFF | 3/30/2025 | ||||||||
| March | 4 | 3/31/2025 | BZZ | Shota Imanaga* | 2L | At | COL | Freddy Peralta | E | |
| March | 5 | 4/1/2025 | BZZ | Logan Webb | 3R | At | COL | Zac Gallen | E | |
| March | 6 | 4/2/2025 | BZZ | Tomoyuki Sugano | 1R | At | COL | Brandon Woodruff | 4L | |
| March | 7 | 4/3/2025 | COL | Emmet Sheehan | 2L | At | CUB | Hunter Greene | 1L | |
| March | 8 | 4/4/2025 | COL | Tarik Skubal* | E | At | CUB | Edward Cabrera | 1R | |
| March | 9 | 4/5/2025 | COL | Freddy Peralta | E | At | CUB | Mackenzie Gore* | 2L | |
| March | 10 | 4/6/2025 | GGG | Dustin May | 3R | At | COL | Zac Gallen | E | |
| March | 11 | 4/7/2025 | GGG | Martin Perez* | 5L | At | COL | Brandon Woodruff | 4L | |
| March | 12 | 4/8/2025 | GGG | Framber Valdez* | 4R | At | COL | Emmet Sheehan | 2L | |
| March | OFF | 4/9/2025 | ||||||||
| March | 13 | 4/10/2025 | COL | Tarik Skubal* | E | At | NYY | Clay Holmes | 1L | |
| March | 14 | 4/11/2025 | COL | Freddy Peralta | E | At | NYY | J.T. Brubaker | 2R | |
| March | 15 | 4/12/2025 | COL | Zac Gallen | E | At | NYY | Ranger Suarez* | 2L | |
| March | 16 | 4/13/2025 | BUR | J.P. Sears* | 1L | At | COL | Brandon Woodruff | 4L | |
| March | 17 | 4/14/2025 | BUR | Bailey Falter* | 1R | At | COL | Emmet Sheehan | 2L | |
| March | 18 | 4/15/2025 | BUR | Brady Singer | 4R | At | COL | Shawn Armstrong | 9R | |
| March | 19 | 4/16/2025 | COL | Tarik Skubal* | E | At | CHI | Dean Kremer | 1R | |
| March | 20 | 4/17/2025 | COL | Freddy Peralta | E | At | CHI | Noah Cameron* | 2L | |
| March | 21 | 4/18/2025 | COL | Zac Gallen | E | At | CHI | Spencer Schwellenbach | 3R | |
| + Indicates In Division Game | ||||||||||