| Month | Game | Strat Date | + | Away | Pitcher | Balance | At | Home | Pitcher | Balance |
| March | 1 | 3/27/2025 | PAT | Jose Berrios | 4L | At | HMA | Carlos Rodon* | E | |
| March | 2 | 3/28/2025 | PAT | Shane Baz | 2L | At | HMA | Jesus Luzardo* | 5L | |
| March | 3 | 3/29/2025 | PAT | Ryne Nelson | 6L | At | HMA | Merrill Kelly | 1R | |
| March | OFF | 3/30/2025 | ||||||||
| March | 4 | 3/31/2025 | HMA | Landen Roupp | 1L | At | WRK | Cristopher Sanchez* | 4L | |
| March | 5 | 4/1/2025 | HMA | Jacob Degrom | 2L | At | WRK | Casey Mize | 1L | |
| March | 6 | 4/2/2025 | HMA | Carlos Rodon* | E | At | WRK | Max Meyer | 8L | |
| March | 7 | 4/3/2025 | HMA | Jesus Luzardo* | 5L | At | GGG | Framber Valdez* | 4R | |
| March | 8 | 4/4/2025 | HMA | Merrill Kelly | 1R | At | GGG | Jack Flaherty | 2R | |
| March | 9 | 4/5/2025 | HMA | Landen Roupp | 1L | At | GGG | Michael Lorenzen | 1L | |
| March | 10 | 4/6/2025 | HMA | Jacob Degrom | 2L | At | CRC | Sonny Gray | 5L | |
| March | 11 | 4/7/2025 | HMA | Carlos Rodon* | E | At | CRC | Michael Wacha | 2L | |
| March | 12 | 4/8/2025 | HMA | Jesus Luzardo* | 5L | At | CRC | Logan Gilbert | 3L | |
| March | OFF | 4/9/2025 | ||||||||
| March | 13 | 4/10/2025 | HUC | Reese Olson | 3L | At | HMA | Merrill Kelly | 1R | |
| March | 14 | 4/11/2025 | HUC | Drew Rasmussen | 3R | At | HMA | Landen Roupp | 1L | |
| March | 15 | 4/12/2025 | HUC | Joe Ryan | 5R | At | HMA | Jacob Degrom | 2L | |
| March | 16 | 4/13/2025 | CHI | Spencer Schwellenbach | 3R | At | HMA | Carlos Rodon* | E | |
| March | 17 | 4/14/2025 | CHI | Aaron Civale | E | At | HMA | Jesus Luzardo* | 5L | |
| March | 18 | 4/15/2025 | CHI | Nick Martinez | 2L | At | HMA | Merrill Kelly | 1R | |
| March | 19 | 4/16/2025 | BUR | Luis Severino | 2R | At | HMA | Landen Roupp | 1L | |
| March | 20 | 4/17/2025 | BUR | Justin Verlander | 1L | At | HMA | Jacob Degrom | 2L | |
| March | 21 | 4/18/2025 | BUR | J.P. Sears* | 1L | At | HMA | Carlos Rodon* | E | |
| + Indicates In Division Game | ||||||||||