| Month | Game | Strat Date | + | Away | Pitcher | Balance | At | Home | Pitcher | Balance |
| April | 1 | 4/19/2025 | TAM | Brayan Bello | E | At | BUR | Bailey Falter* | 1R | |
| April | 2 | 4/20/2025 | TAM | Griffin Canning | E | At | BUR | Brady Singer | 4R | |
| April | 3 | 4/21/2025 | TAM | Cam Schlittler | 1L | At | BUR | Luis Severino | 2R | |
| April | OFF | 4/22/2025 | ||||||||
| April | 4 | 4/23/2025 | HMA | Jacob Degrom | 2L | At | TAM | Chad Patrick | 1R | |
| April | 5 | 4/24/2025 | HMA | Carlos Rodon* | E | At | TAM | Brayan Bello | E | |
| April | 6 | 4/25/2025 | HMA | Nathan Eovaldi | 2R | At | TAM | Grant Holmes | 1L | |
| April | 7 | 4/26/2025 | TAM | Joey Cantillo* | 5R | At | COL | Zac Gallen | E | |
| April | 8 | 4/27/2025 | TAM | Cam Schlittler | 1L | At | COL | Troy Melton | 3R | |
| April | 9 | 4/28/2025 | TAM | Chad Patrick | 1R | At | COL | Tarik Skubal* | E | |
| April | 10 | 4/29/2025 | TAM | Griffin Canning | E | At | CUB | Kyle Hendricks | 4L | |
| April | 11 | 4/30/2025 | TAM | Grant Holmes | 1L | At | CUB | Jake Irvin | 4R | |
| April | 12 | 5/1/2025 | TAM | Joey Cantillo* | 5R | At | CUB | Kodai Senga | 2R | |
| April | OFF | 5/2/2025 | ||||||||
| April | 13 | 5/3/2025 | AAR | Slade Cecconi | 3L | At | TAM | Cam Schlittler | 1L | |
| April | 14 | 5/4/2025 | AAR | Seth Lugo | 7R | At | TAM | Brayan Bello | E | |
| April | 15 | 5/5/2025 | AAR | Zack Littell | 1L | At | TAM | Chad Patrick | 1R | |
| April | 16 | 5/6/2025 | HUC | Johan Oviedo | 1L | At | TAM | Griffin Canning | E | |
| April | 17 | 5/7/2025 | HUC | Cole Ragans* | 1R | At | TAM | Grant Holmes | 1L | |
| April | 18 | 5/8/2025 | HUC | Drew Rasmussen | 3R | At | TAM | Cam Schlittler | 1L | |
| April | 19 | 5/9/2025 | CRC | Sonny Gray | 5L | At | TAM | Joey Cantillo* | 5R | |
| April | 20 | 5/10/2025 | CRC | Michael Wacha | 2L | At | TAM | Brayan Bello | E | |
| April | 21 | 5/11/2025 | CRC | Logan Gilbert | 3L | At | TAM | Griffin Canning | E | |
| + Indicates In Division Game | ||||||||||