| Month | Game | Strat Date | + | Away | Pitcher | Balance | At | Home | Pitcher | Balance |
| April | 1 | 4/19/2025 | TEX | Hunter Brown | E | At | COL | Troy Melton | 3R | |
| April | 2 | 4/20/2025 | TEX | Nick Lodolo* | 5R | At | COL | Ronel Blanco | 7R | |
| April | 3 | 4/21/2025 | TEX | Max Fried* | 2R | At | COL | Tarik Skubal* | E | |
| April | OFF | 4/22/2025 | ||||||||
| April | 4 | 4/23/2025 | TEX | Logan Henderson | 2R | At | DYE | George Kirby | 2R | |
| April | 5 | 4/24/2025 | TEX | Brandon Sproat | 5R | At | DYE | Bryan Woo | E | |
| April | 6 | 4/25/2025 | TEX | Hunter Brown | E | At | DYE | Davis Martin | 2R | |
| April | 7 | 4/26/2025 | BUR | Shane Bieber | 9L | At | TEX | Nick Lodolo* | 5R | |
| April | 8 | 4/27/2025 | BUR | Brady Singer | 4R | At | TEX | Max Fried* | 2R | |
| April | 9 | 4/28/2025 | BUR | Luis Severino | 2R | At | TEX | Logan Henderson | 2R | |
| April | 10 | 4/29/2025 | TEX | Brandon Sproat | 5R | At | WRK | Luis Ortiz | 2R | |
| April | 11 | 4/30/2025 | TEX | Hunter Brown | E | At | WRK | Zack Wheeler | E | |
| April | 12 | 5/1/2025 | TEX | Nick Lodolo* | 5R | At | WRK | Cristopher Sanchez* | 4L | |
| April | OFF | 5/2/2025 | ||||||||
| April | 13 | 5/3/2025 | GGG | Logan Evans | E | At | TEX | Max Fried* | 2R | |
| April | 14 | 5/4/2025 | GGG | Dustin May | 3R | At | TEX | Logan Henderson | 2R | |
| April | 15 | 5/5/2025 | GGG | Stephen Kolek | 1R | At | TEX | Brandon Sproat | 5R | |
| April | 16 | 5/6/2025 | TEX | Hunter Brown | E | At | DUB | Matthew Liberatore* | 1R | |
| April | 17 | 5/7/2025 | TEX | Nick Lodolo* | 5R | At | DUB | Jose Quintana* | 1R | |
| April | 18 | 5/8/2025 | TEX | Max Fried* | 2R | At | DUB | Andrew Abbott* | E | |
| April | 19 | 5/9/2025 | VRN | Yusei Kikuchi* | 2L | At | TEX | Logan Henderson | 2R | |
| April | 20 | 5/10/2025 | VRN | Patrick Corbin* | 2L | At | TEX | Brandon Sproat | 5R | |
| April | 21 | 5/11/2025 | VRN | Sandy Alcantara | 1L | At | TEX | Hunter Brown | E | |
| + Indicates In Division Game | ||||||||||