| Month | Game | Strat Date | + | Away | Pitcher | Balance | At | Home | Pitcher | Balance |
| September | 1 | 8/29/2025 | COL | Brandon Woodruff | 4L | At | HMA | Nathan Eovaldi | 2R | |
| September | 2 | 8/30/2025 | COL | Shawn Armstrong | 9R | At | HMA | Jesus Luzardo* | 5L | |
| September | 3 | 8/31/2025 | COL | Clarke Schmidt | 5R | At | HMA | Jacob Degrom | 2L | |
| September | 4 | 9/1/2025 | DUB | Andrew Abbott* | E | At | COL | Freddy Peralta | E | |
| September | 5 | 9/2/2025 | DUB | David Peterson* | 4L | At | COL | Tarik Skubal* | E | |
| September | 6 | 9/3/2025 | DUB | Mitch Keller | 4R | At | COL | Huascar Brazoban | 9R | |
| September | OFF | 9/4/2025 | ||||||||
| September | 7 | 9/5/2025 | COL | Ronel Blanco | 7R | At | PAT | Max Scherzer | 3R | |
| September | 8 | 9/6/2025 | COL | Brandon Woodruff | 4L | At | PAT | Eury Perez | 1L | |
| September | 9 | 9/7/2025 | COL | Clarke Schmidt | 5R | At | PAT | Jose Berrios | 4L | |
| September | 10 | 9/8/2025 | AAR | Zack Littell | 1L | At | COL | Tyler Holton* | 8L | |
| September | 11 | 9/9/2025 | AAR | Paul Skenes | 2R | At | COL | Freddy Peralta | E | |
| September | 12 | 9/10/2025 | AAR | Seth Lugo | 7R | At | COL | Tarik Skubal* | E | |
| September | 13 | 9/11/2025 | COL | Ronel Blanco | 7R | At | DYE | Jose Soriano | 2L | |
| September | 14 | 9/12/2025 | COL | Brandon Woodruff | 4L | At | DYE | Kolby Allard* | 2R | |
| September | 15 | 9/13/2025 | COL | Clarke Schmidt | 5R | At | DYE | Bryan Woo | E | |
| September | OFF | 9/14/2025 | ||||||||
| September | 16 | 9/15/2025 | + | COL | Freddy Peralta | E | At | HUC | Drew Rasmussen | 3R |
| September | 17 | 9/16/2025 | + | COL | Tarik Skubal* | E | At | HUC | Pablo Lopez | 3R |
| September | 18 | 9/17/2025 | + | COL | Ronel Blanco | 7R | At | HUC | Joe Ryan | 5R |
| September | 19 | 9/18/2025 | + | COL | Brandon Woodruff | 4L | At | HUC | Clayton Kershaw* | 3R |
| September | 20 | 9/19/2025 | + | COL | Clarke Schmidt | 5R | At | HUC | Johan Oviedo | 1L |
| September | 21 | 9/20/2025 | + | NIM | Jeffrey Springs* | 1L | At | COL | Freddy Peralta | E |
| September | 22 | 9/21/2025 | + | NIM | Matt Boyd* | 3L | At | COL | Tarik Skubal* | E |
| September | 23 | 9/22/2025 | + | NIM | Brad Lord | 5R | At | COL | Ronel Blanco | 7R |
| September | 24 | 9/23/2025 | + | NIM | Jameson Taillon | 7L | At | COL | Brandon Woodruff | 4L |
| + Indicates In Division Game | ||||||||||