| Month | Game | Strat Date | + | Away | Pitcher | Balance | At | Home | Pitcher | Balance |
| September | 1 | 8/29/2025 | CUB | Hunter Greene | 1L | At | TAM | Brayan Bello | E | |
| September | 2 | 8/30/2025 | CUB | Yoshinobu Yamamoto | 3L | At | TAM | Trevor Rogers* | 1L | |
| September | 3 | 8/31/2025 | CUB | Mackenzie Gore* | 2L | At | TAM | Grant Holmes | 1L | |
| September | 4 | 9/1/2025 | VRN | Parker Messick* | 3L | At | CUB | Kodai Senga | 2R | |
| September | 5 | 9/2/2025 | VRN | Patrick Corbin* | 2L | At | CUB | Jake Irvin | 4R | |
| September | 6 | 9/3/2025 | VRN | Yusei Kikuchi* | 2L | At | CUB | Hunter Greene | 1L | |
| September | OFF | 9/4/2025 | ||||||||
| September | 7 | 9/5/2025 | + | CRC | Kevin Gausman | 3L | At | CUB | Yoshinobu Yamamoto | 3L |
| September | 8 | 9/6/2025 | + | CRC | Tanner Bibee | 1L | At | CUB | Mackenzie Gore* | 2L |
| September | 9 | 9/7/2025 | + | CRC | Sonny Gray | 5L | At | CUB | Kodai Senga | 2R |
| September | 10 | 9/8/2025 | + | CRC | Michael Wacha | 2L | At | CUB | Jake Irvin | 4R |
| September | 11 | 9/9/2025 | + | CRC | Garrett Crochet* | 5L | At | CUB | Hunter Greene | 1L |
| September | 12 | 9/10/2025 | + | CUB | Yoshinobu Yamamoto | 3L | At | DUB | David Peterson* | 4L |
| September | 13 | 9/11/2025 | + | CUB | Mackenzie Gore* | 2L | At | DUB | Mitch Keller | 4R |
| September | 14 | 9/12/2025 | + | CUB | Kodai Senga | 2R | At | DUB | Ryan Weathers* | 3R |
| September | 15 | 9/13/2025 | + | CUB | Jake Irvin | 4R | At | DUB | Zebby Matthews | 7R |
| September | OFF | 9/14/2025 | ||||||||
| September | 16 | 9/15/2025 | + | BUR | Brady Singer | 4R | At | CUB | Hunter Greene | 1L |
| September | 17 | 9/16/2025 | + | BUR | Luis Severino | 2R | At | CUB | Edward Cabrera | 1R |
| September | 18 | 9/17/2025 | + | BUR | Shane Bieber | 9L | At | CUB | Mackenzie Gore* | 2L |
| September | 19 | 9/18/2025 | + | BUR | J.P. Sears* | 1L | At | CUB | Kodai Senga | 2R |
| September | 20 | 9/19/2025 | + | BUR | Justin Verlander | 1L | At | CUB | Jake Irvin | 4R |
| September | 21 | 9/20/2025 | + | CUB | Hunter Greene | 1L | At | PAT | Jose Berrios | 4L |
| September | 22 | 9/21/2025 | + | CUB | Edward Cabrera | 1R | At | PAT | Logan Allen* | 2L |
| September | 23 | 9/22/2025 | + | CUB | Mackenzie Gore* | 2L | At | PAT | Shane Smith | 4R |
| September | 24 | 9/23/2025 | + | CUB | Kodai Senga | 2R | At | PAT | Max Scherzer | 3R |
| + Indicates In Division Game | ||||||||||