| Month | Game | Strat Date | + | Away | Pitcher | Balance | At | Home | Pitcher | Balance |
| September | 1 | 8/29/2025 | PAT | Max Scherzer | 3R | At | SRD | Kyle Freeland* | 3L | |
| September | 2 | 8/30/2025 | PAT | Eury Perez | 1L | At | SRD | Cade Horton | 3R | |
| September | 3 | 8/31/2025 | PAT | Jose Berrios | 4L | At | SRD | Chris Paddack | E | |
| September | 4 | 9/1/2025 | NIM | Dylan Cease | E | At | PAT | Logan Allen* | 2L | |
| September | 5 | 9/2/2025 | NIM | Matt Boyd* | 3L | At | PAT | Shane Smith | 4R | |
| September | 6 | 9/3/2025 | NIM | Kris Bubic* | 1R | At | PAT | Shane Baz | 2L | |
| September | OFF | 9/4/2025 | ||||||||
| September | 7 | 9/5/2025 | COL | Ronel Blanco | 7R | At | PAT | Max Scherzer | 3R | |
| September | 8 | 9/6/2025 | COL | Brandon Woodruff | 4L | At | PAT | Eury Perez | 1L | |
| September | 9 | 9/7/2025 | COL | Clarke Schmidt | 5R | At | PAT | Jose Berrios | 4L | |
| September | 10 | 9/8/2025 | DYE | Bryan Woo | E | At | PAT | Logan Allen* | 2L | |
| September | 11 | 9/9/2025 | DYE | George Kirby | 2R | At | PAT | Shane Smith | 4R | |
| September | 12 | 9/10/2025 | DYE | Robbie Ray* | 3L | At | PAT | Shane Baz | 2L | |
| September | 13 | 9/11/2025 | PAT | Max Scherzer | 3R | At | AAR | Gavin Williams | 3L | |
| September | 14 | 9/12/2025 | PAT | Eury Perez | 1L | At | AAR | Shohei Ohtani | 8L | |
| September | 15 | 9/13/2025 | PAT | Jose Berrios | 4L | At | AAR | Zack Littell | 1L | |
| September | OFF | 9/14/2025 | ||||||||
| September | 16 | 9/15/2025 | + | PAT | Logan Allen* | 2L | At | CRC | Garrett Crochet* | 5L |
| September | 17 | 9/16/2025 | + | PAT | Shane Smith | 4R | At | CRC | Kevin Gausman | 3L |
| September | 18 | 9/17/2025 | + | PAT | Shane Baz | 2L | At | CRC | Tanner Bibee | 1L |
| September | 19 | 9/18/2025 | + | PAT | Max Scherzer | 3R | At | CRC | Sonny Gray | 5L |
| September | 20 | 9/19/2025 | + | PAT | Eury Perez | 1L | At | CRC | Michael Wacha | 2L |
| September | 21 | 9/20/2025 | + | CUB | Hunter Greene | 1L | At | PAT | Jose Berrios | 4L |
| September | 22 | 9/21/2025 | + | CUB | Edward Cabrera | 1R | At | PAT | Logan Allen* | 2L |
| September | 23 | 9/22/2025 | + | CUB | Mackenzie Gore* | 2L | At | PAT | Shane Smith | 4R |
| September | 24 | 9/23/2025 | + | CUB | Kodai Senga | 2R | At | PAT | Max Scherzer | 3R |
| + Indicates In Division Game | ||||||||||